Reaction Details |
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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Ligand | BDBM14775 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_155175 (CHEMBL761822) |
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IC50 | 3.8±n/a nM |
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Citation | Kleinman, EF; Campbell, E; Giordano, LA; Cohan, VL; Jenkinson, TH; Cheng, JB; Shirley, JT; Pettipher, ER; Salter, ED; Hibbs, TA; DiCapua, FM; Bordner, J Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4. J Med Chem41:266-70 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE1 | NP_000914.2 | PDE21 | PDE4C | PDE4C1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 79875.54 |
Organism: | Homo sapiens (Human) |
Description: | Q08493 |
Residue: | 712 |
Sequence: | MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERD
LSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESF
LYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGA
AKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRI
LNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSA
SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL
KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA
ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL
SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN
LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF
IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL
TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
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BDBM14775 |
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n/a |
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Name | BDBM14775 |
Synonyms: | 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide | 3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxy-benzamide | CHEMBL42126 | Cpodpmb | Piclamilast | RPR-73401 |
Type | Small organic molecule |
Emp. Form. | C18H18Cl2N2O3 |
Mol. Mass. | 381.253 |
SMILES | COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl |
Structure |
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