Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM25981 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1837226 (CHEMBL4337359) |
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Ki | 480±n/a nM |
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Citation | Astolfi, A; Kudolo, M; Brea, J; Manni, G; Manfroni, G; Palazzotti, D; Sabatini, S; Cecchetti, F; Felicetti, T; Cannalire, R; Massari, S; Tabarrini, O; Loza, MI; Fallarino, F; Cecchetti, V; Laufer, SA; Barreca, ML Discovery of potent p38? MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation. Eur J Med Chem182:0 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM25981 |
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n/a |
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Name | BDBM25981 |
Synonyms: | BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | N-(cyclopropylmethyl)-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide | biphenyl amide, 4 |
Type | Small organic molecule |
Emp. Form. | C21H21N3O2 |
Mol. Mass. | 347.4103 |
SMILES | Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCC1CC1 |
Structure |
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