Reaction Details |
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Target | Lanosterol synthase |
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Ligand | BDBM50062846 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_148890 (CHEMBL758671) |
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IC50 | 18000±n/a nM |
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Citation | Ceruti, M; Rocco, F; Viola, F; Balliano, G; Milla, P; Arpicco, S; Cattel, L 29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase. J Med Chem41:540-54 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lanosterol synthase |
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Name: | Lanosterol synthase |
Synonyms: | 2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase |
Type: | PROTEIN |
Mol. Mass.: | 83309.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_11231 |
Residue: | 732 |
Sequence: | MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP
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BDBM50062846 |
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n/a |
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Name | BDBM50062846 |
Synonyms: | 2,2-Dimethyl-3-(3,7,12,19-tetramethyl-16-vinyl-icosa-3,7,11,15,18-pentaenyl)-oxirane | CHEMBL151911 |
Type | Small organic molecule |
Emp. Form. | C30H48O |
Mol. Mass. | 424.7015 |
SMILES | [#6]\[#6](-[#6])=[#6]\[#6]\[#6](-[#6]=[#6])=[#6]/[#6]-[#6]-[#6](-[#6])=[#6]-[#6]-[#6]-[#6]=[#6](-[#6])-[#6]-[#6]-[#6]=[#6](-[#6])-[#6]-[#6]-[#6]1-[#8]C1([#6])[#6] |
Structure |
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