| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK1 |
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| Ligand | BDBM50509920 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1839658 (CHEMBL4339873) |
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| IC50 | 87±n/a nM |
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| Citation |  Zeinyeh, W; Esvan, YJ; Josselin, B; Baratte, B; Bach, S; Nauton, L; Théry, V; Ruchaud, S; Anizon, F; Giraud, F; Moreau, P Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies. Bioorg Med Chem27:2083-2089 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK1 |
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| Name: | Dual specificity protein kinase CLK1 |
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| Synonyms: | CDC-like kinase 1 | CLK1_MOUSE | Clk | Clk1 | Protein kinase STY | Sty |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57124.52 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1502245 |
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| Residue: | 483 |
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| Sequence: | MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESR
SINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRH
HTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDH
KVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVF
ELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDY
TEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCD
VWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDE
HSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLK
KHT
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| BDBM50509920 |
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| n/a |
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| Name | BDBM50509920 |
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| Synonyms: | CHEMBL4558273 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14N6O2 |
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| Mol. Mass. | 298.3 |
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| SMILES | CN(C)CNc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1 |
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| Structure | 
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