| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM50509922 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1839745 (CHEMBL4339960) |
|---|
| Ki | 3.6±n/a nM |
|---|
| Citation |  Dou, F; Cao, X; Jing, P; Wu, C; Zhang, Y; Chen, Y; Zhang, G Synthesis and evaluation of histamine H Bioorg Med Chem Lett29:1492-1496 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 55641.53 |
|---|
| Organism: | Cavia porcellus (domestic guinea pig) |
|---|
| Description: | Guinea pig cerebellum was used in binding assay. |
|---|
| Residue: | 488 |
|---|
| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
|
|
|
|---|
| BDBM50509922 |
|---|
| n/a |
|---|
| Name | BDBM50509922 |
|---|
| Synonyms: | CHEMBL4575319 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H24N2O2 |
|---|
| Mol. Mass. | 288.3847 |
|---|
| SMILES | [H][C@@]12CCC[C@]1([H])CN(CCCOc1ccc(cc1)C(N)=O)C2 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
