| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
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| Ligand | BDBM50510169 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1840685 (CHEMBL4340984) |
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| IC50 | 690±n/a nM |
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| Citation |  Martínez-González, S; Rodríguez-Arístegui, S; Gómez de la Oliva, CA; Hernández, AI; González Cantalapiedra, E; Varela, C; García, AB; Rabal, O; Oyarzabal, J; Bischoff, JR; Klett, J; Albarrán, MI; Cebriá, A; Ajenjo, N; García-Serelde, B; Gómez-Casero, E; Cuadrado-Urbano, M; Cebrián, D; Blanco-Aparicio, C; Pastor, J Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors. Eur J Med Chem168:87-109 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-2 |
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| Name: | Serine/threonine-protein kinase pim-2 |
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| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 34185.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P1W9 |
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| Residue: | 311 |
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| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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| BDBM50510169 |
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| n/a |
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| Name | BDBM50510169 |
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| Synonyms: | CHEMBL4584365 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N8O |
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| Mol. Mass. | 416.479 |
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| SMILES | CN1CCOc2c1cnn1c(nnc21)-c1ccc2cccc(NC3CCNCC3)c2n1 |
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| Structure | 
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