| Reaction Details |
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 | Report a problem with these data |
| Target | Legumain |
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| Ligand | BDBM50510319 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1841425 (CHEMBL4341724) |
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| IC50 | 34±n/a nM |
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| Citation |  Eddie, SL; Gregson, A; Graham, E; Burton, S; Harrison, T; Burden, R; Scott, CJ; Mullan, PB; Williams, R Identification and SAR exploration of a novel series of Legumain inhibitors. Bioorg Med Chem Lett29:1546-1548 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Legumain |
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| Name: | Legumain |
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| Synonyms: | 3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1 |
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| Type: | n/a |
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| Mol. Mass.: | 49411.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 433 |
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| Sequence: | MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNG
IPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGD
AEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYR
KMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMED
SDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASE
AEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHR
IKLSMDHVCLGHY
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| BDBM50510319 |
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| n/a |
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| Name | BDBM50510319 |
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| Synonyms: | CHEMBL4437001 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22FN3O4S |
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| Mol. Mass. | 431.48 |
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| SMILES | CC(C)(CS(=O)(=O)c1ccc(cc1)-c1ccccc1F)C(=O)N[C@@H](CC(N)=O)C#N |r| |
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| Structure | 
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