Reaction Details |
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Target | Oxytocin receptor |
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Ligand | BDBM50064709 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_149175 (CHEMBL762090) |
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Ki | 3.4±n/a nM |
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Citation | Bell, IM; Erb, JM; Freidinger, RM; Gallicchio, SN; Guare, JP; Guidotti, MT; Halpin, RA; Hobbs, DW; Homnick, CF; Kuo, MS; Lis, EV; Mathre, DJ; Michelson, SR; Pawluczyk, JM; Pettibone, DJ; Reiss, DR; Vickers, S; Williams, PD; Woyden, CJ Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines. J Med Chem41:2146-63 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Oxytocin receptor |
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Name: | Oxytocin receptor |
Synonyms: | OT-R | OXYR_RAT | Otr | Oxtr | Oxytocin |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 42889.28 |
Organism: | RAT |
Description: | Oxytocin OXTR RAT::P70536 |
Residue: | 388 |
Sequence: | MEGTPAANWSVELDLGSGVPPGEEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACV
LLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQV
VGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLGTWLGCLVASAPQVHIFSLREV
ADGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAA
AAEGNDAAGGAGRAALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWD
VNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFFCCSARYLKGSRPGETS
VSKKSNSSTFVLSRRSSSQRSCSQPSSA
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BDBM50064709 |
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n/a |
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Name | BDBM50064709 |
Synonyms: | 1-(1-{4-[1-(2-Ethyl-4,6-dimethyl-1-oxy-pyridin-3-ylmethyl)-piperidin-4-yloxy]-5-fluoro-2-methoxy-benzoyl}-piperidin-4-yl)-1,4-dihydro-benzo[d][1,3]oxazin-2-one | CHEMBL66985 |
Type | Small organic molecule |
Emp. Form. | C36H43FN4O6 |
Mol. Mass. | 646.7482 |
SMILES | CCc1c(CN2CCC(CC2)Oc2cc(OC)c(cc2F)C(=O)N2CCC(CC2)N2C(=O)OCc3ccccc23)c(C)cc(C)[n+]1[O-] |
Structure |
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