| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein phosphatase 1 |
|---|
| Ligand | BDBM50510657 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1841934 (CHEMBL4342233) |
|---|
| IC50 | 4800±n/a nM |
|---|
| Citation |  Yeon Kim, B; Hee Yoon, J; Kim, M; Nyoung Kim, J; Park, H; Eon Ryu, S; Lee, S Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition. Bioorg Med Chem Lett29:1746-1748 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein phosphatase 1 |
|---|
| Name: | Dual specificity protein phosphatase 1 |
|---|
| Synonyms: | CL100 | DUS1_HUMAN | DUSP1 | Dual specificity protein phosphatase hVH1 | MAP kinase phosphatase 1 | MKP-1 | MKP1 | PTPN10 | Protein-tyrosine phosphatase CL100 | VH1 |
|---|
| Type: | Protein phosphatase |
|---|
| Mol. Mass.: | 39301.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_4758204 |
|---|
| Residue: | 367 |
|---|
| Sequence: | MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAM
GLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFF
LKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPF
LYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEA
IDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS
FMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSP
ITTSPSC
|
|
|
|---|
| BDBM50510657 |
|---|
| n/a |
|---|
| Name | BDBM50510657 |
|---|
| Synonyms: | CHEMBL4458682 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H14BrN3O2S |
|---|
| Mol. Mass. | 452.324 |
|---|
| SMILES | Brc1ccc(cc1)C(=O)NC(=S)Nc1cccc(c1)-c1nc2ccccc2o1 |
|---|
| Structure | 
|
|---|
Search and Browse
