Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM1080 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_157733 (CHEMBL765171) |
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Ki | 0.088±n/a nM |
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Citation | De Lucca, GV; Kim, UT; Liang, J; Cordova, B; Klabe, RM; Garber, S; Bacheler, LT; Lam, GN; Wright, MR; Logue, KA; Erickson-Viitanen, S; Ko, SS; Trainor, GL Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues. J Med Chem41:2411-23 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM1080 |
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n/a |
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Name | BDBM1080 |
Synonyms: | (4R,5R,6R)-Tetrahydro-1,3-bis[(3-benzamido)methyl]-5-hydroxy-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone | 3-{[(4R,5R,6R)-4-benzyl-3-[(3-carbamoylphenyl)methyl]-5-hydroxy-2-oxo-6-(2-phenylethyl)-1,3-diazinan-1-yl]methyl}benzamide | CHEMBL284340 | Cyclic Urea | Tetrahydropyrimidinone deriv. 23 |
Type | Small organic molecule |
Emp. Form. | C35H36N4O4 |
Mol. Mass. | 576.6847 |
SMILES | NC(=O)c1cccc(CN2[C@H](CCc3ccccc3)[C@@H](O)[C@@H](Cc3ccccc3)N(Cc3cccc(c3)C(N)=O)C2=O)c1 |r| |
Structure |
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