Reaction Details |
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Target | Nitric oxide synthase, brain |
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Ligand | BDBM50230993 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_143509 (CHEMBL755123) |
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IC50 | 7500±n/a nM |
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Citation | Cowart, M; Kowaluk, EA; Daanen, JF; Kohlhaas, KL; Alexander, KM; Wagenaar, FL; Kerwin, JF Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase. J Med Chem41:2636-42 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nitric oxide synthase, brain |
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Name: | Nitric oxide synthase, brain |
Synonyms: | Bnos | N-NOS | NC-NOS | NOS | NOS type I nNOS | NOS1_RAT | Neuronal nitric oxide synthase | Neuronal nitric oxide synthase (nNOS) | Nitric Oxide Synthase, brain | Nitric oxide synthase (nNOS) | Nitric oxide synthase, brain (nNOS) | Nitric-oxide synthase, brain | Nitric-oxide synthase, brain (nNOS) | Nitrogen oxide synthase - neuronal | Nos1 | Peptidyl-cysteine S-nitrosylase NOS1 |
Type: | Enzyme |
Mol. Mass.: | 160570.98 |
Organism: | Rattus norvegicus (rat) |
Description: | Recombinant nNOS overexpressed in E. coli was used in enzyme assays. |
Residue: | 1429 |
Sequence: | MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
GDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
RVTQPLGPPTKAVDLSHQPSASKDQSLAVDRVTGLGNGPQHAQGHGQGAGSVSQANGVAI
DPTMKSTKANLQDIGEHDELLKEIEPVLSILNSGSKATNRGGPAKAEMKDTGIQVDRDLD
GKSHKAPPLGGDNDRVFNDLWGKDNVPVILNNPYSEKEQSPTSGKQSPTKNGSPSRCPRF
LKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPEDVRTKDQLFPLAKE
FLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQ
WSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLI
RYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPEL
VLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCD
NSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIK
HMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTN
GTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHA
FDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKS
YKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVD
TLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKPNNSLISN
DRSWKRNKFRLTYVAEAPDLTQGLSNVHKKRVSAARLLSRQNLQSPKFSRSTIFVRLHTN
GNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWK
DESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKW
GKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTR
DGEGPVHHGVCSSWLNRIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFW
QQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPK
KYVQDVLQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVF
ISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDADEVFSS
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BDBM50230993 |
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n/a |
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Name | BDBM50230993 |
Synonyms: | (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid | (2S)-2-ammonio-5-{[iminio(methylamino)methyl]amino}pentanoate | (R)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | (S)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | (S)-2-amino-5-(2-methylguanidino)pentanoic acid | (S)-2-amino-5-(3-methylguanidino)pentanoic acid | 2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | CHEMBL256147 | L-NMMA | N omega-methyl-L-arginine | N(G)-mono-methyl-L-arginine | N(G)-monomethyl-L-arginine | N-Monomethyl-L-arginine | N-gamma-monomethyl-L-arginine | NG-Monomethyl-L-Arginine | NG-monomethyl-L-arginine acetate | Ngamma-monomethyl-L-arginine | Targinine |
Type | Small organic molecule |
Emp. Form. | C7H16N4O2 |
Mol. Mass. | 188.2275 |
SMILES | CNC(N)=NCCC[C@H](N)C(O)=O |r,w:4.4| |
Structure |
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