| Reaction Details |
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 | Report a problem with these data |
| Target | Perforin-1 |
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| Ligand | BDBM50510947 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1842689 (CHEMBL4343116) |
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| IC50 | 780±n/a nM |
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| Citation |  Spicer, JA; Miller, CK; O'Connor, PD; Jose, J; Giddens, AC; Jaiswal, JK; Jamieson, SMF; Bull, MR; Denny, WA; Akhlaghi, H; Trapani, JA; Hill, GR; Chang, K; Gartlan, KH Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo. J Med Chem63:2229-2239 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Perforin-1 |
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| Name: | Perforin-1 |
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| Synonyms: | PERF_HUMAN | PFP | PRF1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61392.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1285138 |
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| Residue: | 555 |
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| Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
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| BDBM50510947 |
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| n/a |
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| Name | BDBM50510947 |
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| Synonyms: | CHEMBL4453871 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H19F3N4O4S2 |
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| Mol. Mass. | 560.568 |
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| SMILES | COc1ncc(cc1NS(=O)(=O)c1ccccc1C(F)(F)F)-c1ccc(s1)-c1cnc2C(=O)N(C)Cc2c1 |
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| Structure | 
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