| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2B adrenergic receptor |
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| Ligand | BDBM50511341 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1844619 (CHEMBL4345046) |
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| IC50 | 790±n/a nM |
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| Citation |  de Lucas, AI; Vega, JA; Matesanz, E; Linares, ML; García Molina, A; Tresadern, G; Lavreysen, H; Trabanco, AA; Cid, JM Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1 ACS Med Chem Lett11:303-308 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-2B adrenergic receptor |
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| Name: | Alpha-2B adrenergic receptor |
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| Synonyms: | ADA2B_HUMAN | ADRA2B | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR |
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| Type: | Enzyme |
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| Mol. Mass.: | 49964.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18089 |
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| Residue: | 450 |
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| Sequence: | MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL
VATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY
NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGS
FFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASV
ASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEE
EEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRR
AQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS
LNPVIYTIFNQDFRRAFRRILCRPWTQTAW
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| BDBM50511341 |
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| n/a |
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| Name | BDBM50511341 |
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| Synonyms: | CHEMBL4483761 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18BrF3N4O2 |
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| Mol. Mass. | 471.271 |
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| SMILES | CCOc1cc(nnc1C(F)(F)F)N1CCC2(CC1)C(=O)Nc1ccc(Br)cc21 |
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| Structure | 
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