| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin receptor type B |
|---|
| Ligand | BDBM50066391 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_63852 (CHEMBL672282) |
|---|
| Ki | 13000±n/a nM |
|---|
| Citation |  Liu, G; Henry, KJ; Szczepankiewicz, BG; Winn, M; Kozmina, NS; Boyd, SA; Wasicak, J; von Geldern, TW; Wu-Wong, JR; Chiou, WJ; Dixon, DB; Nguyen, B; Marsh, KC; Opgenorth, TJ Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546). J Med Chem41:3261-75 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin receptor type B |
|---|
| Name: | Endothelin receptor type B |
|---|
| Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 49664.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
|---|
| Residue: | 442 |
|---|
| Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
|
|
|
|---|
| BDBM50066391 |
|---|
| n/a |
|---|
| Name | BDBM50066391 |
|---|
| Synonyms: | (2S,3R,4S)-1-Dibutylcarbamoylmethyl-2-(2,2-dimethyl-pentyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-pyrrolidine-3-carboxylic acid | 1-Dibutylcarbamoylmethyl-2-(2,2-dimethyl-pentyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-pyrrolidine-3-carboxylic acid | CHEMBL111612 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H48N2O6 |
|---|
| Mol. Mass. | 532.7119 |
|---|
| SMILES | CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1CC(C)(C)CCC)C(O)=O)c1cc2OCOc2c(OC)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
