| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50066370 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65654 (CHEMBL678074) |
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| Ki | 0.13±n/a nM |
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| Citation |  Liu, G; Henry, KJ; Szczepankiewicz, BG; Winn, M; Kozmina, NS; Boyd, SA; Wasicak, J; von Geldern, TW; Wu-Wong, JR; Chiou, WJ; Dixon, DB; Nguyen, B; Marsh, KC; Opgenorth, TJ Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546). J Med Chem41:3261-75 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50066370 |
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| n/a |
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| Name | BDBM50066370 |
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| Synonyms: | 5-Methyl-pyridine-2-sulfonic acid {6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-[2-(2H-tetrazol-5-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide | CHEMBL109648 | clazosentan |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23N9O6S |
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| Mol. Mass. | 577.572 |
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| SMILES | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(nc1OCCO)-c1ccnc(c1)-c1nnn[nH]1 |
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| Structure | 
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