Ki Summary

Reaction Details

Report a problem with these data

Target

Growth hormone secretagogue receptor type 1

Ligand

BDBM50049479

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_193174 (CHEMBL798749)

EC50

1.7±n/a nM

Citation

Hansen, TK; Ankersen, M; Hansen, BS; Raun, K; Nielsen, KK; Lau, J; Peschke, B; Lundt, BF; Thøgersen, H; Johansen, NL; Madsen, K; Andersen, PH Novel orally active growth hormone secretagogues. J Med Chem41:3705-14 (1998) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Growth hormone secretagogue receptor type 1

Name:

Growth hormone secretagogue receptor type 1

Synonyms:

Type:

PROTEIN

Mol. Mass.:

40970.19

Organism:

Rattus norvegicus

Description:

ChEMBL_11556

Residue:

364

Sequence:

MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGN
LLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQF
VSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVL
VGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWR
RRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQ
YCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKS
SINT

BDBM50049479

n/a

Name

BDBM50049479

Synonyms:

(S)-6-Amino-2-{(R)-2-[(S)-2-{(S)-2-[(R)-2-[(S)-2-amino-3-(1H-imidazol-4-yl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid amide | (S)-6-Amino-2-{(R)-2-[(S)-2-{(S)-2-[(R)-2-[(S)-2-amino-3-(3H-imidazol-4-yl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid amide | CHEMBL105462

Type

Small organic molecule

Emp. Form.

C46H56N12O6

Mol. Mass.

873.0136

SMILES

C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O

Structure