Reaction Details |
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Target | Aldo-keto reductase family 1 member B1 |
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Ligand | BDBM50067392 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_31797 (CHEMBL643203) |
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IC50 | 165±n/a nM |
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Citation | Negoro, T; Murata, M; Ueda, S; Fujitani, B; Ono, Y; Kuromiya, A; Komiya, M; Suzuki, K; Matsumoto, J Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners. J Med Chem41:4118-29 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B1 |
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Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | AKR1B1 | ALDR_PIG | ALR2 | AR | Aldose reductase |
Type: | PROTEIN |
Mol. Mass.: | 35865.31 |
Organism: | Sus scrofa |
Description: | ChEMBL_502637 |
Residue: | 316 |
Sequence: | MASHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQ
EKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGK
DPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKP
AVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
YNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCA
LMSCASHKDYPFHEEY
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BDBM50067392 |
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n/a |
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Name | BDBM50067392 |
Synonyms: | CHEMBL134089 | [2-(4-Bromo-2-fluoro-benzyl)-1,3-dioxo-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-4-yl]-acetic acid |
Type | Small organic molecule |
Emp. Form. | C16H12BrFN2O4 |
Mol. Mass. | 395.18 |
SMILES | OC(=O)CC1C(=O)N(Cc2ccc(Br)cc2F)C(=O)c2cccn12 |
Structure |
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