Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50067865 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_55108 (CHEMBL665435) |
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IC50 | 0.4±n/a nM |
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Citation | Gangjee, A; Zhu, Y; Queener, SF 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents. J Med Chem41:4533-41 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21638.84 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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BDBM50067865 |
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n/a |
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Name | BDBM50067865 |
Synonyms: | CHEMBL337603 | N*6*-(3,4-Dimethoxy-phenyl)-N*6*-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine |
Type | Small organic molecule |
Emp. Form. | C16H18N6O2 |
Mol. Mass. | 326.3531 |
SMILES | COc1ccc(cc1OC)N(C)c1ccc2nc(N)nc(N)c2n1 |
Structure |
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