| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Ligand | BDBM50067865 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_53457 (CHEMBL661507) |
|---|
| IC50 | 0.88±n/a nM |
|---|
| Citation |  Gangjee, A; Zhu, Y; Queener, SF 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents. J Med Chem41:4533-41 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Name: | Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Synonyms: | DHFR-TS | DRTS_TOXGO | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; T. gondii vs rat |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68757.49 |
|---|
| Organism: | Toxoplasma gondii |
|---|
| Description: | Q07422 |
|---|
| Residue: | 610 |
|---|
| Sequence: | MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKT
GDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEG
QQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPC
DVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNG
VPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE
DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYS
LDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHR
EVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAA
LDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKP
KEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP
HGRIQMEMAV
|
|
|
|---|
| BDBM50067865 |
|---|
| n/a |
|---|
| Name | BDBM50067865 |
|---|
| Synonyms: | CHEMBL337603 | N*6*-(3,4-Dimethoxy-phenyl)-N*6*-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H18N6O2 |
|---|
| Mol. Mass. | 326.3531 |
|---|
| SMILES | COc1ccc(cc1OC)N(C)c1ccc2nc(N)nc(N)c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
