| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 4 |
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| Ligand | BDBM209265 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1850434 (CHEMBL4351058) |
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| IC50 | 18±n/a nM |
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| Citation |  Gehringer, M; Laufer, SA Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology. J Med Chem62:5673-5724 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 4 |
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| Name: | Fibroblast growth factor receptor 4 |
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| Synonyms: | CD_antigen=CD334 | FGFR4_MOUSE | Fgfr-4 | Fgfr4 | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 | Mpk-11 | Protein-tyrosine kinase receptor MPK-11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 88660.29 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_820929 |
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| Residue: | 799 |
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| Sequence: | MWLLLALLSIFQGTPALSLEASEEMEQEPCLAPILEQQEQVLTVALGQPVRLCCGRTERG
RHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLLMDDSLTS
ISNDEDPKTLSSSSSGHVYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIH
WLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLE
RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHVVINGSSFGADGFPYVQ
VLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDLTWTTATP
EARYTDIILYVSGSLVLLVLLLLAGVYHRQVIRGHYSRQPVTIQKLSRFPLARQFSLESR
SSGKSSLSLVRGVRLSSSGPPLLTGLVNLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVR
AEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQE
GPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYL
ESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD
RVYTHQSDVWSFEILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMR
ECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPFSPSNGDASSTCSSSDSVFS
HDPLPLEPSPFPFSDSQTT
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| BDBM209265 |
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| n/a |
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| Name | BDBM209265 |
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| Synonyms: | US9266883, 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N5O4 |
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| Mol. Mass. | 381.3853 |
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| SMILES | COCCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N |
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| Structure | 
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