| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Ligand | BDBM50512901 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1850563 (CHEMBL4351187) |
|---|
| IC50 | 15400±n/a nM |
|---|
| Citation |  Silbermann, K; Stefan, SM; Elshawadfy, R; Namasivayam, V; Wiese, M Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach. J Med Chem62:4383-4400 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
|---|
| Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
|---|
| Mol. Mass.: | 72329.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UNQ0 |
|---|
| Residue: | 655 |
|---|
| Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
|
|
|
|---|
| BDBM50512901 |
|---|
| n/a |
|---|
| Name | BDBM50512901 |
|---|
| Synonyms: | CHEMBL1722772 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H26N6O |
|---|
| Mol. Mass. | 462.5456 |
|---|
| SMILES | O=C(N1CCN(Cc2ccc(cc2)C#N)CC1)c1cn(Cc2ccccc2)nc1-c1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
