| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B |
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| Ligand | BDBM50359391 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1852475 (CHEMBL4353099) |
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| IC50 | 43±n/a nM |
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| Citation |  Zhang, P; Xu, S; Zhu, Z; Xu, J Multi-target design strategies for the improved treatment of Alzheimer's disease. Eur J Med Chem176:228-247 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] B |
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| Name: | Amine oxidase [flavin-containing] B |
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| Synonyms: | AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 58469.65 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P19643 |
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| Residue: | 520 |
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| Sequence: | MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWR
TMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQ
TGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVY
YKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEER
LRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGK
IFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNT
FLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
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| BDBM50359391 |
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| n/a |
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| Name | BDBM50359391 |
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| Synonyms: | CHEMBL1929421 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H37N3O |
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| Mol. Mass. | 443.6236 |
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| SMILES | CN(CC#C)Cc1cc2cc(OCCCC3CCN(Cc4ccccc4)CC3)ccc2n1C |
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| Structure | 
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