| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Plasmepsin II |
|---|
| Ligand | BDBM50513809 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1854563 (CHEMBL4355292) |
|---|
| IC50 | 10.0±n/a nM |
|---|
| Citation |  Bobrovs, R; Jaudzems, K; Jirgensons, A Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases. J Med Chem62:8931-8950 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Plasmepsin II |
|---|
| Name: | Plasmepsin II |
|---|
| Synonyms: | Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51482.09 |
|---|
| Organism: | Plasmodium falciparum |
|---|
| Description: | P46925 |
|---|
| Residue: | 453 |
|---|
| Sequence: | MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
|
|
|
|---|
| BDBM50513809 |
|---|
| n/a |
|---|
| Name | BDBM50513809 |
|---|
| Synonyms: | CHEMBL4558109 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C38H47N3O3 |
|---|
| Mol. Mass. | 593.7981 |
|---|
| SMILES | CN(CCc1ccccc1)C(=O)C1=C(CC2CN(CC1N2)C(C)=O)c1ccc(CCOc2ccc(cc2C)C(C)(C)C)cc1 |t:13| |
|---|
| Structure | 
|
|---|
Search and Browse
