Reaction Details |
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Target | Plasmepsin II |
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Ligand | BDBM50513836 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1854563 (CHEMBL4355292) |
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IC50 | 10.0±n/a nM |
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Citation | Bobrovs, R; Jaudzems, K; Jirgensons, A Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases. J Med Chem62:8931-8950 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Plasmepsin II |
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Name: | Plasmepsin II |
Synonyms: | Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II |
Type: | Enzyme |
Mol. Mass.: | 51482.09 |
Organism: | Plasmodium falciparum |
Description: | P46925 |
Residue: | 453 |
Sequence: | MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
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BDBM50513836 |
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n/a |
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Name | BDBM50513836 |
Synonyms: | CHEMBL4536043 |
Type | Small organic molecule |
Emp. Form. | C36H43N3O3 |
Mol. Mass. | 565.7449 |
SMILES | CC(C)c1ccccc1OCCc1ccc(cc1)C1=C(C2CN(CC(C1)N2)C(C)=O)C(=O)N(C)CCc1ccccc1 |t:20| |
Structure |
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