Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50069214 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_101751 |
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Ki | 15±n/a nM |
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Citation | Jacobson, IC; Reddy, PG; Wasserman, ZR; Hardman, KD; Covington, MB; Arner, EC; Copeland, RA; Decicco, CP; Magolda, RL Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett8:837-42 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50069214 |
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n/a |
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Name | BDBM50069214 |
Synonyms: | (2R,3R)-N*4*-((S)-5-Amino-1-methylcarbamoyl-pentyl)-2,N*1*-dihydroxy-2-methyl-3-(3-phenyl-propyl)-succinamide | CHEMBL408682 |
Type | Small organic molecule |
Emp. Form. | C21H34N4O5 |
Mol. Mass. | 422.5185 |
SMILES | CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCc1ccccc1)[C@@](C)(O)C(=O)NO |
Structure |
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