| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 5 |
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| Ligand | BDBM50398716 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1854952 (CHEMBL4355681) |
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| IC50 | 6620±n/a nM |
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| Citation |  Shen, S; Hadley, M; Ustinova, K; Pavlicek, J; Knox, T; Noonepalle, S; Tavares, MT; Zimprich, CA; Zhang, G; Robers, MB; Ba?inka, C; Kozikowski, AP; Villagra, A Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem62:8557-8577 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 5 |
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| Name: | Histone deacetylase 5 |
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| Synonyms: | Antigen NY-CO-9 | HD5 | HDAC5 | HDAC5_HUMAN | Histone acetylase 5 (HDAC5) | Histone deacetylase 5 (HDAC5) | Human HDAC5 | KIAA0600 |
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| Type: | Enzyme |
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| Mol. Mass.: | 121968.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UQL6 |
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| Residue: | 1122 |
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| Sequence: | MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELR
GALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQ
QEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKL
PLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEI
TGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMST
SSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATS
MRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEED
CIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQ
SSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE
TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLP
CGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAM
GFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF
FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVS
AGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVS
ALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET
EEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
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| BDBM50398716 |
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| n/a |
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| Name | BDBM50398716 |
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| Synonyms: | CHEMBL2179618 | US10227295, Compound 5g | US9409858, 5g | US9751832, Compound 5g | US9956192, Compound 5g |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N3O3 |
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| Mol. Mass. | 341.4042 |
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| SMILES | CCCCN(Cc1ccc(cc1)C(=O)NO)C(=O)Nc1ccccc1 |
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| Structure | 
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