| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 4 |
|---|
| Ligand | BDBM50514113 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1855687 (CHEMBL4356416) |
|---|
| IC50 | 50±n/a nM |
|---|
| Citation |  Schauer, NJ; Magin, RS; Liu, X; Doherty, LM; Buhrlage, SJ Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors. J Med Chem63:2731-2750 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ubiquitin carboxyl-terminal hydrolase 4 |
|---|
| Name: | Ubiquitin carboxyl-terminal hydrolase 4 |
|---|
| Synonyms: | Deubiquitinating enzyme 4 | UBP4_HUMAN | UNP | UNPH | USP4 | Ubiquitin thioesterase 4 | Ubiquitin-specific-processing protease 4 | Ubiquitous nuclear protein homolog |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 108549.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_107635 |
|---|
| Residue: | 963 |
|---|
| Sequence: | MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG
EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK
VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE
TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRN
FTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPG
LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK
QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL
KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP
LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN
HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASAL
YGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGED
EEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADI
NSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRD
CIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDT
VVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDS
NVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSM
DTN
|
|
|
|---|
| BDBM50514113 |
|---|
| n/a |
|---|
| Name | BDBM50514113 |
|---|
| Synonyms: | CHEMBL4593739 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H15ClN2O2 |
|---|
| Mol. Mass. | 314.766 |
|---|
| SMILES | Cn1cc(cc1C(=O)NCc1ccc(cc1)C#C)C(=O)CCl |
|---|
| Structure | 
|
|---|
Search and Browse
