Reaction Details |
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Target | Monoglyceride lipase |
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Ligand | BDBM46658 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1855763 (CHEMBL4356492) |
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IC50 | 307±n/a nM |
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Citation | Castelli, R; Scalvini, L; Vacondio, F; Lodola, A; Anselmi, M; Vezzosi, S; Carmi, C; Bassi, M; Ferlenghi, F; Rivara, S; Møller, IR; Rand, KD; Daglian, J; Wei, D; Dotsey, EY; Ahmed, F; Jung, KM; Stella, N; Singh, S; Mor, M; Piomelli, D Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines. J Med Chem63:1261-1280 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Monoglyceride lipase |
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Name: | Monoglyceride lipase |
Synonyms: | MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL) |
Type: | Enzyme |
Mol. Mass.: | 33505.38 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q8R431 |
Residue: | 303 |
Sequence: | MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLG
HSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRID
SSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGAR
CLP
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BDBM46658 |
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n/a |
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Name | BDBM46658 |
Synonyms: | 1,2-benzothiazol-3-one | MLS-0254244.0001 | US9011882, Table 1, Compound 20 | acs.jmedchem.1c00409_ST.166 | cid_17520 |
Type | Small organic molecule |
Emp. Form. | C7H5NOS |
Mol. Mass. | 151.186 |
SMILES | O=c1[nH]sc2ccccc12 |
Structure |
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