| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50514182 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1855763 (CHEMBL4356492) |
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| IC50 | 56±n/a nM |
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| Citation |  Castelli, R; Scalvini, L; Vacondio, F; Lodola, A; Anselmi, M; Vezzosi, S; Carmi, C; Bassi, M; Ferlenghi, F; Rivara, S; Møller, IR; Rand, KD; Daglian, J; Wei, D; Dotsey, EY; Ahmed, F; Jung, KM; Stella, N; Singh, S; Mor, M; Piomelli, D Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines. J Med Chem63:1261-1280 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL) |
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| Type: | Enzyme |
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| Mol. Mass.: | 33505.38 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q8R431 |
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| Residue: | 303 |
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| Sequence: | MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLG
HSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRID
SSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGAR
CLP
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| BDBM50514182 |
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| n/a |
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| Name | BDBM50514182 |
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| Synonyms: | CHEMBL3219170 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15NOS |
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| Mol. Mass. | 233.329 |
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| SMILES | O=c1n(sc2ccccc12)C1CCCCC1 |
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| Structure | 
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