| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
|---|
| Ligand | BDBM50514253 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1855924 (CHEMBL4356653) |
|---|
| Ki | 11±n/a nM |
|---|
| Citation |  García, M; Virgili, M; Alonso, M; Alegret, C; Fernández, B; Port, A; Pascual, R; Monroy, X; Vidal-Torres, A; Serafini, MT; Vela, JM; Almansa, C 4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual ?-Opioid Receptor Agonists and ? J Med Chem63:2434-2454 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sigma non-opioid intracellular receptor 1 |
|---|
| Name: | Sigma non-opioid intracellular receptor 1 |
|---|
| Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 25124.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q99720 |
|---|
| Residue: | 223 |
|---|
| Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
|
|
|
|---|
| BDBM50514253 |
|---|
| n/a |
|---|
| Name | BDBM50514253 |
|---|
| Synonyms: | CHEMBL4584335 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27FN2O2 |
|---|
| Mol. Mass. | 382.4711 |
|---|
| SMILES | CC1OC2(CCN(CCc3ccccc3)CC2)CN(C1=O)c1ccccc1F |
|---|
| Structure | 
|
|---|
Search and Browse
