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TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
LigandBDBM50514365
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1856476 (CHEMBL4357205)
IC50 2.5±n/a nM
Citation Patel, KD; De Zoysa, GH; Kanamala, M; Patel, K; Pilkington, LI; Barker, D; Reynisson, J; Wu, Z; Sarojini, V Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations. J Med Chem63:334-348 (2020) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
Name:A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
Synonyms:20S proteasome | 26S proteosome
Type:n/a
Mol. Mass.:n/a
Description:Combinations of UniProts
Components:This complex has 19 components.
Component 1
Name:Proteasome subunit beta type-2
Synonyms:20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:PROTEIN
Mol. Mass.:22837.53
Organism:Homo sapiens (Human)
Description:ChEMBL_1294233
Residue:201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYI
QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDY
LAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSV
RIIDKNGIHDLDNISFPKQGS
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Component 2
Name:Proteasome subunit beta type-1
Synonyms:PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:PROTEIN
Mol. Mass.:26493.62
Organism:Homo sapiens (Human)
Description:ChEMBL_1366691
Residue:241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEG
FSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAML
STILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQ
VGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRK
D
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Component 3
Name:Proteasome subunit beta type-5
Synonyms:20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:Protein
Mol. Mass.:28480.96
Organism:Homo sapiens (Human)
Description:n/a
Residue:263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
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Component 4
Name:Proteasome subunit beta type-8
Synonyms:26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2
Type:PROTEIN
Mol. Mass.:30357.49
Organism:Homo sapiens (Human)
Description:ChEMBL_1446797
Residue:276
Sequence:
MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
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Component 5
Name:Proteasome subunit beta type-9
Synonyms:LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein
Type:PROTEIN
Mol. Mass.:23256.49
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:219
Sequence:
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHER
IYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMV
AGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIA
LAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
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Component 6
Name:Proteasome subunit beta type-6
Synonyms:LMPY | Macropain delta chain | Multicatalytic endopeptidase complex delta chain | PSB6_HUMAN | PSMB6 | Proteasome delta chain | Proteasome subunit Y | Y
Type:PROTEIN
Mol. Mass.:25349.89
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:239
Sequence:
MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
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Component 7
Name:Proteasome subunit alpha type-1
Synonyms:30 kDa prosomal protein | HC2 | Macropain subunit C2 | Multicatalytic endopeptidase complex subunit C2 | NU | PROS-30 | PROS30 | PSA1_HUMAN | PSC2 | PSMA1 | Proteasome component C2 | Proteasome nu chain
Type:PROTEIN
Mol. Mass.:29555.77
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:263
Sequence:
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ
KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPT
QRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM
ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP
QRKAQPAQPADEPAEKADEPMEH
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Component 8
Name:Proteasome subunit alpha type-2
Synonyms:HC3 | Macropain subunit C3 | Multicatalytic endopeptidase complex subunit C3 | PSA2_HUMAN | PSC3 | PSMA2 | Proteasome component C3
Type:PROTEIN
Mol. Mass.:25900.29
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:234
Sequence:
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER
SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE
YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE
DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA
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Component 9
Name:Proteasome subunit alpha type-3
Synonyms:HC8 | Macropain subunit C8 | Multicatalytic endopeptidase complex subunit C8 | PSA3_HUMAN | PSC8 | PSMA3 | Proteasome component C8
Type:PROTEIN
Mol. Mass.:28426.36
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:255
Sequence:
MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE
EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV
HAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL
QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA
KESLKEEDESDDDNM
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Component 10
Name:Proteasome subunit alpha type-4
Synonyms:HC9 | Macropain subunit C9 | Multicatalytic endopeptidase complex subunit C9 | PSA4_HUMAN | PSC9 | PSMA4 | Proteasome component C9 | Proteasome subunit L
Type:PROTEIN
Mol. Mass.:29486.50
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:261
Sequence:
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF
FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA
YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYK
EGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKH
EEEEAKAEREKKEKEQKEKDK
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Component 11
Name:Proteasome subunit alpha type-5
Synonyms:Macropain zeta chain | Multicatalytic endopeptidase complex zeta chain | PSA5_HUMAN | PSMA5 | Proteasome zeta chain
Type:PROTEIN
Mol. Mass.:26398.14
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:241
Sequence:
MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLME
PSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA
LQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSS
LQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKD
I
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Component 12
Name:Proteasome subunit alpha type-6
Synonyms:27 kDa prosomal protein | Macropain iota chain | Multicatalytic endopeptidase complex iota chain | PROS-27 | PROS27 | PSA6_HUMAN | PSMA6 | Proteasome iota chain | p27K
Type:PROTEIN
Mol. Mass.:27399.66
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:246
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
ALAERD
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Component 13
Name:Proteasome subunit alpha type-7
Synonyms:HSPC | PSA7_HUMAN | PSMA7 | Proteasome subunit RC6-1 | Proteasome subunit XAPC7
Type:PROTEIN
Mol. Mass.:27891.04
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:248
Sequence:
MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVR
KICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQ
SNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEA
IETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENE
KKKQKKAS
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Component 14
Name:Proteasome subunit alpha-type 8
Synonyms:PSMA7L | PSMA8 | PSMA8_HUMAN | Proteasome subunit alpha type-7-like
Type:PROTEIN
Mol. Mass.:28537.53
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:256
Sequence:
MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT
VRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA
TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL
EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI
EKEKEEAEKKKSKKSV
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Component 15
Name:Proteasome subunit beta type-10
Synonyms:LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i
Type:PROTEIN
Mol. Mass.:28940.51
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:273
Sequence:
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT
NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR
ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR
FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR
YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
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Component 16
Name:Proteasome subunit beta type-11
Synonyms:PSB11_HUMAN | PSMB11 | Proteasome subunit beta-5t
Type:PROTEIN
Mol. Mass.:32529.58
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:300
Sequence:
MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHG
VIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREG
QLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSG
SPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSD
ACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV
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Component 17
Name:Proteasome subunit beta type-3
Synonyms:PSB3_HUMAN | PSMB3 | Proteasome chain 13 | Proteasome component C10-II | Proteasome theta chain
Type:PROTEIN
Mol. Mass.:22948.68
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:205
Sequence:
MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDV
QTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPF
ICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAV
SGMGVIVHIIEKDKITTRTLKARMD
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Component 18
Name:Proteasome subunit beta type-4
Synonyms:26 kDa prosomal protein | HsBPROS26 | HsN3 | Macropain beta chain | Multicatalytic endopeptidase complex beta chain | PROS-26 | PROS26 | PSB4_HUMAN | PSMB4 | Proteasome beta chain | Proteasome chain 3
Type:PROTEIN
Mol. Mass.:29202.40
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:264
Sequence:
MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVK
FEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEE
LLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAP
SLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEK
GVEIEGPLSTETNWDIAHMISGFE
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Component 19
Name:Proteasome subunit beta type-7
Synonyms:Macropain chain Z | Multicatalytic endopeptidase complex chain Z | PSB7_HUMAN | PSMB7 | Proteasome subunit Z | Z
Type:PROTEIN
Mol. Mass.:29968.13
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:277
Sequence:
MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD
TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV
TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV
FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT
RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
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BDBM50514365
n/a
NameBDBM50514365
Synonyms:CHEMBL4587036
TypeSmall organic molecule
Emp. Form.C90H162N38O20
Mol. Mass.2096.4919
SMILESCC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C=O |r|
Structure
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