| Reaction Details |
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 | Report a problem with these data |
| Target | Cruzipain |
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| Ligand | BDBM50514690 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1858190 (CHEMBL4358919) |
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| Ki | 5500±n/a nM |
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| Citation |  Chenna, BC; Li, L; Mellott, DM; Zhai, X; Siqueira-Neto, JL; Calvet Alvarez, C; Bernatchez, JA; Desormeaux, E; Alvarez Hernandez, E; Gomez, J; McKerrow, JH; Cruz-Reyes, J; Meek, TD Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity. J Med Chem63:3298-3316 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cruzipain |
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| Name: | Cruzipain |
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| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
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| Type: | Protein |
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| Mol. Mass.: | 49831.41 |
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| Organism: | Trypanosoma cruzi |
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| Description: | P25779 |
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| Residue: | 467 |
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| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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| BDBM50514690 |
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| n/a |
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| Name | BDBM50514690 |
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| Synonyms: | CHEMBL4454970 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H31N3O3 |
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| Mol. Mass. | 505.6068 |
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| SMILES | O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)\C=C\c1ccncc1)OCc1ccccc1 |r| |
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| Structure | 
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