| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
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| Ligand | BDBM50514752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1858295 (CHEMBL4359024) |
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| IC50 | 32300±n/a nM |
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| Citation |  Serafini, M; Torre, E; Aprile, S; Grosso, ED; Gesł, A; Griglio, A; Colombo, G; Travelli, C; Paiella, S; Adamo, A; Orecchini, E; Coletti, A; Pallotta, MT; Ugel, S; Massarotti, A; Pirali, T; Fallarini, S Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to J Med Chem63:3047-3065 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 2,3-dioxygenase |
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| Name: | Tryptophan 2,3-dioxygenase |
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| Synonyms: | T23O_MOUSE | TO | TRPO | Tdo | Tdo2 | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47757.90 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1452150 |
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| Residue: | 406 |
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| Sequence: | MSGCPFAGNSVGYTLKNVSMEDNEEDRAQTGVNRASKGGLIYGNYLQLEKILNAQELQSE
VKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVIARMHRVVV
IFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHY
RDNFGGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPNGFNFWGKFEKNILKGLEEEFLR
IQAKTDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGTKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLVPRHWVPKMNPIIHKFLYTAEYSDSSYFSSDESD
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| BDBM50514752 |
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| n/a |
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| Name | BDBM50514752 |
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| Synonyms: | CHEMBL4458549 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18N4O |
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| Mol. Mass. | 366.4152 |
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| SMILES | O=C(NCc1cccc(Cn2cnc3ccccc23)c1)c1ccc(cc1)C#N |
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| Structure | 
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