| Reaction Details |
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 | Report a problem with these data |
| Target | Sepiapterin reductase |
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| Ligand | BDBM50515126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1860096 (CHEMBL4360952) |
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| IC50 | 40±n/a nM |
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| Citation |  Alen, J; Schade, M; Wagener, M; Christian, F; Nordhoff, S; Merla, B; Dunkern, TR; Bahrenberg, G; Ratcliffe, P Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J Med Chem62:6391-6397 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sepiapterin reductase |
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| Name: | Sepiapterin reductase |
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| Synonyms: | SPR | SPRE_HUMAN | Sepiapterin reductase (SPR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 28050.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35270 |
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| Residue: | 261 |
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| Sequence: | MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG
LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV
NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML
FQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQK
LLSLLEKDEFKSGAHVDFYDK
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| BDBM50515126 |
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| n/a |
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| Name | BDBM50515126 |
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| Synonyms: | CHEMBL4451547 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H16FNO3S |
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| Mol. Mass. | 285.334 |
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| SMILES | Oc1cc(F)ccc1S(=O)(=O)N1CCC2(CCC2)C1 |
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| Structure | 
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