| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene monooxygenase |
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| Ligand | BDBM50070340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_201930 (CHEMBL809117) |
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| IC50 | 80±n/a nM |
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| Citation |  Gotteland, JP; Loubat, C; Planty, B; Junquéro, D; Delhon, A; Halazy, S Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors. Bioorg Med Chem Lett8:1337-42 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene monooxygenase |
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| Name: | Squalene monooxygenase |
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| Synonyms: | ERG1 | ERG1_HUMAN | SE | SQLE | Squalene epoxidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63936.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_201924 |
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| Residue: | 574 |
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| Sequence: | MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSG
SQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSS
QNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGL
GDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAE
PNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKV
SVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYM
VEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGG
MTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSAT
DDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPW
ITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
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| BDBM50070340 |
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| n/a |
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| Name | BDBM50070340 |
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| Synonyms: | CHEMBL281025 | Thiophene-2-sulfonic acid [2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-methyl-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34N2O3S2 |
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| Mol. Mass. | 474.679 |
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| SMILES | CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCCN(C)S(=O)(=O)c2cccs2)c1 |
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| Structure | 
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