| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
|---|
| Ligand | BDBM50515321 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1860828 (CHEMBL4361684) |
|---|
| Ki | 1000±n/a nM |
|---|
| Citation |  Murineddu, G; Gotti, C; Asproni, B; Corona, P; Martinello, K; Plutino, S; Fucile, S; Temml, V; Moretti, M; Viani, P; Schuster, D; Piras, S; Deligia, F; Pinna, GA Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors. Eur J Med Chem180:51-61 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor subunit alpha-7 |
|---|
| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
|---|
| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56502.44 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q05941 |
|---|
| Residue: | 502 |
|---|
| Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
|
|
|
|---|
| BDBM50515321 |
|---|
| n/a |
|---|
| Name | BDBM50515321 |
|---|
| Synonyms: | CHEMBL4543232 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22N4O |
|---|
| Mol. Mass. | 334.4149 |
|---|
| SMILES | O=C(N1CCc2ccccc2C1)c1cncc(c1)N1CC2CC(C1)N2 |TLB:16:18:24:21| |
|---|
| Structure | 
|
|---|
Search and Browse
