| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Estradiol 17-beta-dehydrogenase 2 |
|---|
| Ligand | BDBM50515437 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1861100 (CHEMBL4361956) |
|---|
| IC50 | 47±n/a nM |
|---|
| Citation |  Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW Design, Synthesis, and Biological Characterization of Orally Active 17?-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis. J Med Chem62:7289-7301 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Estradiol 17-beta-dehydrogenase 2 |
|---|
| Name: | Estradiol 17-beta-dehydrogenase 2 |
|---|
| Synonyms: | 17-beta-HSD 2 | 17-beta-hydroxysteroid dehydrogenase type 2 | DHB2_MOUSE | Edh17b2 | Hsd17b2 | Testosterone 17-beta-dehydrogenase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 41847.95 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_104366 |
|---|
| Residue: | 381 |
|---|
| Sequence: | MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFL
LSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGP
GAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGEL
IPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAAL
TMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDY
VHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLL
DYVIKKGFYPQPTPRALRTVH
|
|
|
|---|
| BDBM50515437 |
|---|
| n/a |
|---|
| Name | BDBM50515437 |
|---|
| Synonyms: | CHEMBL4471724 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H12ClF3N2O4S2 |
|---|
| Mol. Mass. | 524.92 |
|---|
| SMILES | Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccc(Cl)nc3)c2)c1F |
|---|
| Structure | 
|
|---|
Search and Browse
