Reaction Details |
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Target | Estradiol 17-beta-dehydrogenase 2 |
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Ligand | BDBM50515435 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1861111 (CHEMBL4361967) |
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IC50 | 9.0±n/a nM |
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Citation | Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW Design, Synthesis, and Biological Characterization of Orally Active 17?-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis. J Med Chem62:7289-7301 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Estradiol 17-beta-dehydrogenase 2 |
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Name: | Estradiol 17-beta-dehydrogenase 2 |
Synonyms: | 17-beta-HSD 2 | 17-beta-hydroxysteroid dehydrogenase type 2 | DHB2_RAT | Edh17b2 | Estradiol 17-beta-dehydrogenase 2 | Hsd17b2 | Testosterone 17-beta-dehydrogenase |
Type: | PROTEIN |
Mol. Mass.: | 41973.66 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_104364 |
Residue: | 381 |
Sequence: | MNPFSSESAWLCLTATAVLGGMLLCKAWSSGQLRSQVVCLAGLWGGACLLSLSLLCSLFL
LSVSCFFLLYVSSSDQDLLPVDQKAVLVTGADSGFGHALAKHLDKLGFTVFAGVLDKEGP
GAEELRKNCSERLSVLQMDVTKPEQIKDVHSEVAEKIQDKGLWAVVNNAGVLHFPIDGEL
IPMTVYRKCMAVNFFGAVEVTKVFLPLLRKSKGRLVNVSSMGAMIPFQMVAAYASTKAAI
SMFSAVIRQELAKWGVKVVTIHPGGFQTNIVGSQDSWDKMEKEILDHFSKEIQENYGQEY
VHTQKLALPVMREMSNPDITPVLRDIQHAICAKNPSSFYCSGRMTYLWICFAAYSPISLL
DYILKNYFTPKLMPRALRTAS
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BDBM50515435 |
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n/a |
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Name | BDBM50515435 |
Synonyms: | CHEMBL4513439 |
Type | Small organic molecule |
Emp. Form. | C23H11F6NO4S2 |
Mol. Mass. | 543.458 |
SMILES | Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cc(NS(=O)(=O)c3ccc(F)cc3)c(F)cc2F)c1F |
Structure |
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