| Reaction Details |
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 | Report a problem with these data |
| Target | Estradiol 17-beta-dehydrogenase 1 |
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| Ligand | BDBM50515434 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1861112 (CHEMBL4361968) |
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| IC50 | 9.0±n/a nM |
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| Citation |  Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW Design, Synthesis, and Biological Characterization of Orally Active 17?-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis. J Med Chem62:7289-7301 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estradiol 17-beta-dehydrogenase 1 |
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| Name: | Estradiol 17-beta-dehydrogenase 1 |
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| Synonyms: | 17-beta-HSD 1 | 17-beta-hydroxysteroid dehydrogenase type 1 | DHB1_RAT | Edh17b1 | Estradiol 17-beta-dehydrogenase 1 | Hsd17b1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36963.81 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104363 |
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| Residue: | 344 |
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| Sequence: | MDSTVVLITGCSSGIGLHLAVRLASDRSQSFKVYATLRDLKSQGPLLEAARAQGCPPGSL
EILELDVRDSESVAAARACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTI
RMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVH
VSLIECGAVHTAFHEKLEGGPGGALERADAQTRHLFAHYQRGYEQALSEAQDPEEVTELF
LTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVEAMHREAFSDLQVQEGAKAGAQVS
GDPDTPPRALICLPECAIPRVTAELGWSASDKPGQNKSCYQQKI
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| BDBM50515434 |
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| n/a |
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| Name | BDBM50515434 |
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| Synonyms: | CHEMBL4518587 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H13F4NO4S2 |
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| Mol. Mass. | 507.477 |
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| SMILES | Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccccc2NS(=O)(=O)c2ccc(F)cc2)c1F |
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| Structure | 
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