| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
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| Ligand | BDBM50515543 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1861503 (CHEMBL4362359) |
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| IC50 | 21±n/a nM |
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| Citation |  Travelli, C; Aprile, S; Mattoteia, D; Colombo, G; Clemente, N; Scanziani, E; Terrazzino, S; Alisi, MA; Polenzani, L; Grosa, G; Genazzani, AA; Tron, GC; Galli, U Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group. Eur J Med Chem181:0 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide phosphoribosyltransferase |
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| Name: | Nicotinamide phosphoribosyltransferase |
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| Synonyms: | NAMPT_MOUSE | NAmPRTase | Nampt | Pbef1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55450.71 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_108315 |
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| Residue: | 491 |
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| Sequence: | MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVP
EGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNA
QLNIEQDVAPH
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| BDBM50515543 |
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| n/a |
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| Name | BDBM50515543 |
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| Synonyms: | CHEMBL4464821 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H41N9O3 |
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| Mol. Mass. | 599.7264 |
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| SMILES | CCOC(=O)C1CCN(Cc2cn(nn2)-c2ccccc2C(=O)NCCCCCCCn2cc(nn2)-c2cccnc2)CC1 |
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| Structure | 
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