Reaction Details |
| Report a problem with these data |
Target | Prothrombin |
---|
Ligand | BDBM50070824 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_208345 |
---|
Ki | 0.120000±n/a nM |
---|
Citation | Isaacs, RC; Cutrona, KJ; Newton, CL; Sanderson, PE; Solinsky, MG; Baskin, EP; Chen, IW; Cooper, CM; Cook, JJ; Gardell, SJ; Lewis, SD; Lucas, RJ; Lyle, EA; Lynch, JJ; Naylor-Olsen, AM; Stranieri, MT; Vastag, K; Vacca, JP C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption. Bioorg Med Chem Lett8:1719-24 (1999) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prothrombin |
---|
Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
Type: | Protein |
Mol. Mass.: | 70029.57 |
Organism: | Homo sapiens (Human) |
Description: | P00734 |
Residue: | 622 |
Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
|
|
|
BDBM50070824 |
---|
n/a |
---|
Name | BDBM50070824 |
Synonyms: | CHEMBL47920 | N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-[3-(4-chloro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-acetamide |
Type | Small organic molecule |
Emp. Form. | C22H24ClN5O4S |
Mol. Mass. | 489.975 |
SMILES | Cc1ccc(NS(=O)(=O)Cc2ccc(Cl)cc2)c(=O)n1CC(=O)NCc1ccc(N)nc1C |
Structure |
|