Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM50069959 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_52890 |
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Ki | 12±n/a nM |
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Citation | Batt, DG; Petraitis, JJ; Sherk, SR; Copeland, RA; Dowling, RL; Taylor, TL; Jones, EA; Magolda, RL; Jaffee, BD Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents. Bioorg Med Chem Lett8:1745-50 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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BDBM50069959 |
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n/a |
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Name | BDBM50069959 |
Synonyms: | Brequinar sodium | CHEMBL300058 | Sodium; 6-fluoro-2-(2'-fluoro-biphenyl-4-yl)-3-methyl-quinoline-4-carboxylate | US10919869, Brequinar |
Type | Small organic molecule |
Emp. Form. | C23H14F2NO2 |
Mol. Mass. | 374.3601 |
SMILES | Cc1c(nc2ccc(F)cc2c1C([O-])=O)-c1ccc(cc1)-c1ccccc1F |
Structure |
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