| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Ligand | BDBM50070854 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_52890 |
|---|
| Ki | 34±n/a nM |
|---|
| Citation |  Batt, DG; Petraitis, JJ; Sherk, SR; Copeland, RA; Dowling, RL; Taylor, TL; Jones, EA; Magolda, RL; Jaffee, BD Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents. Bioorg Med Chem Lett8:1745-50 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42881.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q02127 |
|---|
| Residue: | 395 |
|---|
| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
|
|
|
|---|
| BDBM50070854 |
|---|
| n/a |
|---|
| Name | BDBM50070854 |
|---|
| Synonyms: | CHEMBL50279 | Sodium; 6-fluoro-2-[4-(3-methoxy-phenyl)-2,3-dihydro-indol-1-yl]-3-methyl-quinoline-4-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H20FN2O3 |
|---|
| Mol. Mass. | 427.4476 |
|---|
| SMILES | COc1cccc(c1)-c1cccc2N(CCc12)c1nc2ccc(F)cc2c(C([O-])=O)c1C |
|---|
| Structure | 
|
|---|
Search and Browse
