| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 1 |
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| Ligand | BDBM50300229 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1863380 (CHEMBL4364236) |
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| IC50 | 3484±n/a nM |
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| Citation |  Fan, TY; Wu, WY; Yu, SP; Zhong, Y; Zhao, C; Chen, M; Li, HM; Li, NG; Chen, Z; Chen, S; Sun, ZH; Duan, JA; Shi, ZH Design, synthesis and evaluation of 2-amino-imidazol-4-one derivatives as potent ?-site amyloid precursor protein cleaving enzyme 1 (BACE-1) inhibitors. Bioorg Med Chem Lett29:0 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-secretase 1 |
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| Name: | Beta-secretase 1 |
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| Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
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| Type: | Protein |
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| Mol. Mass.: | 55755.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56817 |
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| Residue: | 501 |
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| Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
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| BDBM50300229 |
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| n/a |
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| Name | BDBM50300229 |
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| Synonyms: | 1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-amine | 2-Imino-3-methyl-5,5-diphenyl-imidazolidin-4-one | 2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-one | 5,5-Diphenyl-2-iminohydantoin | CHEMBL291784 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15N3O |
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| Mol. Mass. | 265.3098 |
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| SMILES | CN1C(N)=NC(C1=O)(c1ccccc1)c1ccccc1 |c:3| |
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| Structure | 
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