| Reaction Details |
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 | Report a problem with these data |
| Target | Estradiol 17-beta-dehydrogenase 2 |
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| Ligand | BDBM50466002 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1863754 (CHEMBL4364729) |
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| IC50 | 25±n/a nM |
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| Citation |  Abdelsamie, AS; Salah, M; Siebenbürger, L; Hamed, MM; Börger, C; van Koppen, CJ; Frotscher, M; Hartmann, RW Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17?-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation. Eur J Med Chem178:93-107 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estradiol 17-beta-dehydrogenase 2 |
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| Name: | Estradiol 17-beta-dehydrogenase 2 |
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| Synonyms: | 17-beta-HSD 2 | 17-beta-hydroxysteroid dehydrogenase type 2 | DHB2_MOUSE | Edh17b2 | Hsd17b2 | Testosterone 17-beta-dehydrogenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41847.95 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_104366 |
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| Residue: | 381 |
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| Sequence: | MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFL
LSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGP
GAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGEL
IPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAAL
TMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDY
VHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLL
DYVIKKGFYPQPTPRALRTVH
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| BDBM50466002 |
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| n/a |
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| Name | BDBM50466002 |
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| Synonyms: | CHEMBL4285743 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H13F6NO5S2 |
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| Mol. Mass. | 573.484 |
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| SMILES | Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3OC(F)(F)F)c2)c1F |
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| Structure | 
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