Reaction Details |
| Report a problem with these data |
Target | Endothelin receptor type B |
---|
Ligand | BDBM50071445 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_64012 |
---|
Ki | 0.140000±n/a nM |
---|
Citation | Sakaki, J; Murata, T; Yuumoto, Y; Nakamura, I; Trueh, T; Pitterna, T; Iwasaki, G; Oda, K; Yamamura, T; Hayakawa, K Discovery of IRL 3461: a novel and potent endothelin antagonist with balanced ETA/ETB affinity. Bioorg Med Chem Lett8:2241-6 (1999) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Endothelin receptor type B |
---|
Name: | Endothelin receptor type B |
Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49664.00 |
Organism: | Homo sapiens (Human) |
Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
Residue: | 442 |
Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
|
|
|
BDBM50071445 |
---|
n/a |
---|
Name | BDBM50071445 |
Synonyms: | CHEMBL310039 | N-[(R)-1-[(S)-2-Ethenesulfonylamino-1-(1H-indol-3-ylmethyl)-2-oxo-ethylcarbamoyl]-2-(4-isoxazol-5-yl-phenyl)-ethyl]-3,5,N-trimethyl-benzamide |
Type | Small organic molecule |
Emp. Form. | C35H35N5O6S |
Mol. Mass. | 653.747 |
SMILES | CN([C@H](Cc1ccc(cc1)-c1ccno1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NS(=O)(=O)C=C)C(=O)c1cc(C)cc(C)c1 |
Structure |
|