| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kelch-like ECH-associated protein 1 |
|---|
| Ligand | BDBM50516724 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1866580 (CHEMBL4367555) |
|---|
| Kd | 29±n/a nM |
|---|
| Citation |  Lu, MC; Zhang, X; Wu, F; Tan, SJ; Zhao, J; You, QD; Jiang, ZY Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity. J Med Chem62:6796-6813 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kelch-like ECH-associated protein 1 |
|---|
| Name: | Kelch-like ECH-associated protein 1 |
|---|
| Synonyms: | Cytosolic inhibitor of Nrf2 | INRF2 | KEAP1 | KEAP1/Cullin-3/Microtubule-associated protein tau | KEAP1_HUMAN | KIAA0132 | KLHL19 | Kelch-like protein 19 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 69664.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_107924 |
|---|
| Residue: | 624 |
|---|
| Sequence: | MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
|
|
|
|---|
| BDBM50516724 |
|---|
| n/a |
|---|
| Name | BDBM50516724 |
|---|
| Synonyms: | CHEMBL4588743 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H24N2O7S |
|---|
| Mol. Mass. | 484.522 |
|---|
| SMILES | COc1ccc(cc1)S(=O)(=O)N(CC(O)=O)c1ccc(N2CCC[C@H]2C(O)=O)c2ccccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
