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TargetMannose-6-phosphate isomerase
LigandBDBM50071531
Substrate/Competitorn/a
Meas. Tech.ChEMBL_222751 (CHEMBL846957)
Ki 4000±n/a nM
Citation Bhandari, AJones, DGSchullek, JRVo, KSchunk, CATamanaha, LLChen, DYuan, ZNeedels, MCGallop, MA Exploring structure-activity relationships around the phosphomannose isomerase inhibitor AF14049 via combinatorial synthesis. Bioorg Med Chem Lett8:2303-8 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Mannose-6-phosphate isomerase
Name:Mannose-6-phosphate isomerase
Synonyms:MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:PROTEIN
Mol. Mass.:46651.35
Organism:Homo sapiens (Human)
Description:ChEMBL_1448919
Residue:423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL
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  Blast E-value cutoff:
BDBM50071531
n/a
NameBDBM50071531
Synonyms:2-[4-(2,4-Dichloro-phenoxy)-butyrylamino]-indan-2-carboxylic acid amide | CHEMBL76175
TypeSmall organic molecule
Emp. Form.C20H20Cl2N2O3
Mol. Mass.407.29
SMILESNC(=O)C1(Cc2ccccc2C1)NC(=O)CCCOc1ccc(Cl)cc1Cl
Structure
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