| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
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| Ligand | BDBM50071665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_221490 |
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| IC50 | 600±n/a nM |
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| Citation |  Bullington, JL; Cameron, JC; Davis, JE; Dodd, JH; Harris, CA; Henry, JR; Pellegrino-Gensey, JL; Rupert, KC; Siekierka, JJ The development of novel and selective p56lck tyrosine kinase inhibitors. Bioorg Med Chem Lett8:2489-94 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lck |
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| Name: | Tyrosine-protein kinase Lck |
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| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
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| Type: | n/a |
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| Mol. Mass.: | 57987.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06239 |
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| Residue: | 509 |
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| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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| BDBM50071665 |
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| n/a |
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| Name | BDBM50071665 |
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| Synonyms: | 5-Amino-2-[1-(3,4-dihydroxy-phenyl)-meth-(E)-ylidene]-indan-1,3-dione | CHEMBL81793 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11NO4 |
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| Mol. Mass. | 281.2628 |
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| SMILES | Nc1ccc2C(=O)\C(=C/c3ccc(O)c(O)c3)C(=O)c2c1 |
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| Structure | 
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