| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
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| Ligand | BDBM50071667 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_161406 (CHEMBL768315) |
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| IC50 | 5000±n/a nM |
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| Citation |  Bullington, JL; Cameron, JC; Davis, JE; Dodd, JH; Harris, CA; Henry, JR; Pellegrino-Gensey, JL; Rupert, KC; Siekierka, JJ The development of novel and selective p56lck tyrosine kinase inhibitors. Bioorg Med Chem Lett8:2489-94 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
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| Name: | cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
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| Synonyms: | cAMP-dependent protein kinase (PKA) |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 217489 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | cAMP-dependent protein kinase catalytic subunit beta |
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| Synonyms: | KAPCB_HUMAN | PKA C-beta | PKAC-beta | PRKACB | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase beta-1 catalytic subunit | cAMP-dependent protein kinase catalytic subunit beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40631.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586348 |
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| Residue: | 351 |
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| Sequence: | MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML
VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT
TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
|
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| Component 2 |
| Name: | cAMP-dependent protein kinase catalytic subunit alpha |
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| Synonyms: | KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit |
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| Type: | Enzyme Catalytic Subunit |
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| Mol. Mass.: | 40598.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 351 |
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| Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML
VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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| Component 3 |
| Name: | cAMP-dependent protein kinase catalytic subunit gamma |
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| Synonyms: | KAPCG_HUMAN | PKA C-gamma | PRKACG | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic subunit gamma |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40442.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104720 |
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| Residue: | 351 |
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| Sequence: | MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML
VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV
MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY
LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY
ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT
TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
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| BDBM50071667 |
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| n/a |
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| Name | BDBM50071667 |
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| Synonyms: | 5-Amino-2-[1-(3,5-dichloro-4-hydroxy-phenyl)-meth-(E)-ylidene]-indan-1,3-dione | CHEMBL84808 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H9Cl2NO3 |
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| Mol. Mass. | 334.154 |
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| SMILES | Nc1ccc2C(=O)\C(=C/c3cc(Cl)c(O)c(Cl)c3)C(=O)c2c1 |
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| Structure | 
|
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